Simona Halep, who has been suspended since October due to a positive test for a banned substance, faces a second doping accusation.
Reuters reported that the latest charge comes from her Athlete Biological Passport that showed irregularities in her profile.
"We understand that today's announcement adds complexity to an already high-profile situation. ... We have remained committed to engaging with Ms. Halep in an empathetic, efficient and timely manner," Nicole Sapstead, senior director for anti-doping at the International Tennis Integrity Agency, said in a statement.